
Born: June 5, 1829, Rogoźno (Rogasen), Grand Duchy of Posen.
Died: October 13, 1903, Germantown, Philadelphia, Pennsylvania.
Buried: Rodeph Shalom Cemetery, Philadelphia, Pennsylvania.

Marcus was the son of Abraham Jastrow and Yetta (Henrietta) Rolle, and husband of Bertha J. Wolfsohn.
After receiving rabbinical ordination, PhD, and a Doctorate of Letters, he became rabbi of the then Orthodox Congregation Rodeph Shalom in Philadelphia, Pennsylvania, in 1866.
In 1886, he began publishing his magnum opus, A Dictionary of the Targumim, Talmud Babli, Talmud Yerushalmi and Midrashic Literature, in pamphlet form. It was finally completed and published in two-volume form in 1903, and is a popular resource for students of the Talmud.
Jastrow was also responsible for most Talmud-related articles in the Jewish Encyclopedia.