Born: September 6, 1840, Rock Island, Illinois.
Died: September 25, 1901, Philadelphia, Pennsylvania.
Buried: Chippiannock Cemetery, Rock Island, Illinois.
William was the son of John Winchell Spencer and Eliza W. Wilson, husband of Eliza Boyle Sargent, and father of composer Clarissa Spencer.
From 1867–85, he served numerous Methodist Episcopal (ME) churches in the Rock River Conference (northern Illinois).
He was senior pastor of the First ME Church in Chicago, Illinois, for six weeks in 1885, when he was elected to serve as assistant corresponding secretary of the ME Board of Church Extension, Philadelphia, Pennsylvania.