Born: September 27, 1879, Shades Valley (near Birmingham), Alabama.
Died: May 10, 1949, Fort Worth, Texas.
Buried: Greenwood Cemetery, Fort Worth, Texas.
Isham was the husband of Lura Hawk.
He attended the Normal Singing Schools run by Henry Showalter and John Herbert (1902–03); Mississippi College (1905–06); Moody Bible Institute (1907–08), Chicago, Illinois; Siegel-Myers University Correspondence School of Music (BM 1918) and the Chicago Musical College (1920). In 1942, he received a MusD degree from the Southern School of Fine Arts in Houston, Texas.
He was a member of the Cumberland Presbyterian Church and later the Highland Baptist Church in Birmingham, Alabama. For about a decade starting around 1905, he was a singing evangelist under the auspices of the Mississippi Baptist State Mission Board and the Southern Baptist Home Mission Board.